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Isaac Deng

Isaac Deng

Isaac, a Sydney medical student, focuses on oncology and neuroscience. His work spans in vivo mouse research and directed evolution for novel biologics. He also hosts Denversations, a podcast on science, innovation, and society.

📍 Sydney, Australia

Issue 6 — Cadherins Pt. 1

Issue 6 — Cadherins Pt. 1

Dysfunction of classical cadherins is a hallmark of cancer development and progression. They are also linked to sensorial disorders such as hereditary deafness. This piece begins the series on cadherins, allowing us to in the future assess their roles in cancer and neurobiology.

Issue 5 — Tight junction Claudins

Issue 5 — Tight junction Claudins

Claudins are the principal structural proteins of tight junctions. They dynamically regulate cell–cell adhesion, serving both as physical connectors and as selective channels that control paracellular ion flow. Altered claudin expression or function is implicated in various cancers.

Issue 4: Vascular Specialisation and Barrier Function

Issue 4: Vascular Specialisation and Barrier Function

This educational piece is designed for medical students and others interested in human physiology. Here, I introduce key concepts in the regulation and maintenance of the body’s fluid compartments

Issue 3 — On the Blood Brain Barrier

A horizontal review

Issue 2 - INTRODUCTION TO CANCER BIOLOGY: THE SOMATIC MUTATION THEORY

Issue 2 - INTRODUCTION TO CANCER BIOLOGY: THE SOMATIC MUTATION THEORY

What is cancer? That's a hard question, but I'd answer like this: Cancer is a Darwinian, somatic evolutionary process driven by the sequential accumulation of genetic and structural alterations in individual cells. This offers some introduction to the theoretical frameworks of this definition

Introduction to Neuroscience — Issue 1

Hello all, welcome to this new weekly newsletter where I will endeavour to describe and make more accessible neuroscientific and oncological knowledge and findings.

Welcome to Neuroscience and Oncology with Isaac

Clear perspectives at the frontiers of neuroscience and oncology.